Ardelyx, Inc.
GLYCYRRHETINIC ACID DERIVATIVES FOR TREATING HYPERKALEMIA

Abstract:

The present invention provides a compound of formula (I) or a salt thereof: (I) wherein X, L, V, R.sub.1, R.sub.2, R.sub.3 and R.sub.4, are as defined herein. These compounds are inhibitors of 11-hydroxysteroid dehydrogenase type 2 (11-HSD-2) and are used to treat hyperkalemia. ##STR00001##