Aerpio Pharmaceuticals, Inc.
Combinations of Tie-2 Activators and Prostaglandins and Uses Thereof

Abstract:

Described herein are combinations of compounds effective for activation of Tie-2 and inhibition of HPTP.beta. with a compound that causes agonism of a prostaglandin receptor. The methods and compositions of the invention can be used for the treatment of glaucoma, elevated intraocular pressure, ocular hypertension, and associated conditions by, for example, reduction of intraocular pressure in the eye.