Arrowhead Pharmaceuticals, Inc.
INTEGRIN LIGANDS AND USES THEREOF

Abstract:

Synthetic av.beta.6 integrin ligands of Formula I having serum stability and affinity for integrin av.beta.6, which is a receptor expressed in a variety of cell types, are described. The described ligands are useful for delivering cargo molecules, such as RNAi agents or other oligonucleotide-based compounds, to cells that express integrin av.beta.6, and thereby facilitating the uptake of the cargo molecules into these cells. Compositions that include avB6 integrin ligands and methods of use are also described. ##STR00001##