Ascendis Pharma A/S
TREATMENT OF INFECTIONS

Abstract:

The present invention relates among other aspects to a conjugate or a pharmaceutically acceptable salt thereof or a pharmaceutical composition comprising said conjugate or its pharmaceutically acceptable salt for use in a method of preventing or treating an infection, wherein said conjugate is water-insoluble and comprises a polymeric moiety --Z to which a plurality of moieties -L.sup.2-X.sup.0D-L.sup.1-D are covalently conjugated, wherein each -D is independently an antibiotic moiety; each -L.sup.1- is independently a linker moiety to which -D is covalently and reversibly conjugated; each --X.sup.0D-- is independently absent or a linkage and each -L.sup.2- is independently either a chemical bond or a spacer moiety.