Actinium Pharmaceuticals, Inc.
Antibodies Conjugated With Actinium-225 and Actinium-227, and Related Compositions and Methods

Abstract:

This invention provides a compositions of matter comprising a therapeutic protein population (such as a HuM195 antibody population) wherein (a) each therapeutic protein in the population is conjugated to one or more actinium atoms, (b) each actinium atom is either .sup.227Ac or .sub.225Ac, and (c) the molar ratio of .sup.227Ac to .sup.225Ac in the composition is at least 1:1, This invention also provides related synthetic compositions and methods, as well as methods for treating hematologic malignancies.