Baxter International Inc.
DETERMINATION OF KINETIC DEGRADATION OF IRON-CARBOHYDRATE COMPLEXES

Abstract:

An analytical method for measuring degradation of iron-carbohydrate complex for intravenous injection may include formulating a reaction solution comprising an iron-carbohydrate complex for intravenous injection, a reducing agent, and a complexing agent. The method may further include measuring absorbance spectral absorbance of an iron-complexing agent species including all or a portion of the complexing agent and iron released from the iron-carbohydrate complex that has been reduced by the reducing agent. Example complexing agents may include 1,10 phenanthroline or ferrozine. An example, iron-carbohydrate complex may be iron sucrose injection.