BioCryst Pharmaceuticals, Inc.
Methods and compositions for treatment of zika virus infection

Abstract:

Disclosed are 9-deazaaadenine derivatives of the general formula (I) ##STR00001## and pharmaceutically acceptable salts thereof, wherein A is OH or NH.sub.2, and B is H or NH.sub.2. Methods for treating, preventing and/or suppressing a Zika virus infection with the compounds disclosed are also provided. Pharmaceutical compositions comprising the disclosed compounds are also provided. Such pharmaceutical compositions may optionally contain one or more additional active agents.