Biohaven Pharmaceutical Holding Company Ltd.
Prodrugs of riluzole and their method of use
Last updated:
Abstract:
Pharmaceutical compositions of the invention include substituted riluzole prodrugs useful for the treatment of cancers including melanoma, breast cancer, brain cancer, and prostate cancer through the release of riluzole. Prodrugs of riluzole have enhanced stability to hepatic metabolism and are delivered into systemic circulation by oral administration, and then cleaved to release riluzole in the plasma via either an enzymatic or general biophysical release process.
Status:
Grant
Type:
Utility
Filling date:
23 Nov 2020
Issue date:
13 Sep 2022