Bristol-Myers Squibb Company
Substituted bicyclic compounds

Abstract:

Disclosed are compounds of Formulas (I), (II), (III), (IV), and (V): ##STR00001## and/or a salt thereof, wherein R.sub.1 is --OH or --OP(O)(OH).sub.2, and X.sub.1, X.sub.2, X.sub.3, R.sub.2, R.sub.2a, R.sub.a, R.sub.b, and R.sub.c are defined herein. Also disclosed are methods of using such compounds as selective agonists for G protein-coupled receptor S1P.sub.1, and pharmaceutical compositions comprising such compounds. These compounds are useful in treating, preventing, or slowing the progression of diseases or disorders in a variety of therapeutic areas, such as autoimmune diseases and vascular disease.