Bristol-Myers Squibb Company
Heterocyclic compounds useful as modulators of TNF alpha

Abstract:

Disclosed are compounds of Formula (I) or a salt thereof, wherein: A is CR.sub.1 or N; B is CR.sub.3 or N; D is CR.sub.4 or N; L.sub.1 is --(CR.sub.7R.sub.7).sub.m--; L.sub.2 is --(CR.sub.7R.sub.7).sub.n--; and X, Z, R.sub.1, R.sub.2, R.sub.3, R.sub.4, R.sub.5, and R.sub.6 are define herein. Also disclosed are methods of using such compounds as modulators of TNF.alpha., and pharmaceutical compositions comprising such compounds. These compounds are useful in treating inflammatory and autoimmune diseases. ##STR00001##