Bristol-Myers Squibb Company
Substituted bicyclic heterocyclic compounds

Abstract:

Disclosed are compounds of Formula (I), or a salt thereof, wherein: X is CR.sub.4 or N; Y is CR.sub.4 or N, provided that Y is N only if X is N; R.sub.1 is Formulae (A) or (B); each W is independently NR.sub.1b or O; Z is a bond or CHR.sub.1d; and R.sub.1, R.sub.2, R.sub.3, R.sub.4, L.sub.1, R.sub.1a, R.sub.1b, R.sub.1c, and n are defined herein. Also disclosed are methods of using such compounds as inhibitors of ROMK, and pharmaceutical compositions comprising such compounds. These compounds are useful in treating cardiovascular diseases. ##STR00001##