Bristol-Myers Squibb Company
Thienopyridines and benzothiophenes useful as IRAK4 inhibitors

Abstract:

Disclosed are compounds of Formula (I) or a salt or prodrug thereof, wherein: X is CR.sub.4 or N; Y is CR.sub.5 or N; provided that only one of X and Y is N; (R1) is: or; wherein R.sub.1, R.sub.1a, R.sub.1b, R.sub.1c, R.sub.2, and R.sub.3 are define herein. Also disclosed are methods of using such compounds as modulators of IRAK4, and pharmaceutical compositions comprising such compounds. These compounds are useful in treating, preventing, or slowing inflammatory and autoimmune diseases, or in the treatment of cancer. ##STR00001##