Bristol-Myers Squibb Company
Interleukin-2/interleukin-2 receptor alpha fusion proteins and methods of use

Abstract:

Disclosed herein are fusion proteins comprising: (a) a first polypeptide comprising Interleukin-2 (IL2); and (b) a second polypeptide, fused in frame to the first polypeptide, wherein the second polypeptide comprises an extracellular domain of Interleukin-2 Receptor alpha (IL2R.alpha.), wherein IL2 or IL2R.alpha. comprises at least one fewer glycosylation site compared to native IL2 or native IL2R.alpha.. Methods of production and methods of therapeutic use of the fusion proteins are also disclosed.