Bristol-Myers Squibb Company
Amide-substituted heterocyclic compounds useful as modulators of IL-12, IL-23 and/or IFN.alpha. responses

Abstract:

Compounds having the following formula I: or a stereoisomer or pharmaceutically-acceptable salt thereof, where R.sup.1, R.sup.2, R.sup.3, R.sup.4, and R.sup.5 are as defined herein, are useful in the modulation of IL-12, IL-23 and/or IFN.alpha., by acting on Tyk-2 to cause signal transduction inhibition. ##STR00001##