Bristol-Myers Squibb Company
Glypican-3-binding fibronectin based scaffold molecules

Abstract:

Provided herein are polypeptides which include tenth fibronectin type III domains (.sup.10Fn3) that bind to glypican-3. Also provided are fusion molecules comprising a .sup.10Fn3 domain that bind to glypican-3 for use in diagnostic and therapeutic applications. Glypican-3 .sup.10Fn3 drug conjugates are also provided.