Bristol-Myers Squibb Company
Prodrugs of imidazotriazine compounds as CK2 inhibitors

Abstract:

The invention provides pharmaceutically active compounds of formula (I) and prodrugs thereof. The formula (I) 2-(aminophenylamino)-4-amino-7-cyano-imidazo[2,1-f][1,2,4]triazine derivatives inhibit CK2 protein kinase activity, thereby making them useful for treating cancer, psoriasis and rheumatoid arthritis. ##STR00001##