Bristol-Myers Squibb Company
Aryl substituted bicycle heteroaryl compounds

Abstract:

Disclosed is a compound of Formula (I) or a stereoisomer, tautomer, pharmaceutically acceptable salt, solvate or prodrug thereof, wherein one R.sub.3 is H and the other R.sub.3 is an aryl group substituted with zero to 3 R.sub.3a; and R.sub.1, R.sub.2, and R.sub.3a are defined herein. Also disclosed are methods of using such compounds as PAR4 inhibitors for the inhibition or prevention of platelet aggregation, and the treatment of a thromboembolic disorder or the primary prophylaxis of a thromboembolic disorder. Also disclosed are methods of using such compounds for the treatment of human papillomavirus. Additionally, pharmaceutical compositions comprising at least one compound of Formula (I) are disclosed. ##STR00001##