Bristol-Myers Squibb Company
Substituted tetrahydrocarbazole and carbazole carboxamide compounds

Abstract:

Disclosed are compounds of Formula (I) ##STR00001## wherein: the two dotted lines represent either two single or two double bonds; Q is: ##STR00002## R.sub.1 is F, Cl, --CN, or --CH.sub.3; R.sub.2 is Cl or --CH.sub.3; R.sub.3 is --C(CH.sub.3).sub.2OH or --CH.sub.2CH.sub.2OH; R.sub.a is H or --CH.sub.3; each R.sub.b is independently F, Cl, --CH.sub.3, and/or --OCH.sub.3; and n is zero, 1, or 2. Also disclosed are methods of using such compounds as inhibitors of Bruton's tyrosine kinase (Btk), and pharmaceutical compositions comprising such compounds. These compounds are useful in treating, preventing, or slowing the progression of diseases or disorders in a variety of therapeutic areas, such as autoimmune diseases and vascular disease.