Bristol-Myers Squibb Company
Phthalazinones and isoquinolinones as rock inhibitors

Abstract:

The present invention provides compounds of Formula (I): ##STR00001## or stereoisomers, tautomers, or pharmaceutically acceptable salts thereof, wherein all the variables are as defined herein. These compounds are selective ROCK inhibitors. This invention also relates to pharmaceutical compositions comprising these compounds and methods of treating cardiovascular, smooth muscle, oncologic, neuropathologic, autoimmune, fibrotic, and/or inflammatory disorders using the same.