Bristol-Myers Squibb Company
OXIME ETHER COMPOUNDS

Abstract:

Disclosed are compounds of Formula (I): (I) or a salt thereof, wherein: X is CH or N; Y is CH or N; R.sub.1 is --OH or --OP(O)(OH).sub.2; L.sub.1 is --CR.sub.3.dbd.N--O--CR.sub.aR.sub.a-- or CR.sub.aR--O--N.dbd.CR.sub.3; L.sub.2 is a bond, --C(O)--, or S(O).sub.2--; and R.sub.2, R.sub.3, R.sub.a, m, and n are defined herein. Also disclosed are methods of using such compounds as selective agonists for G protein coupled receptor S1P1, and pharmaceutical compositions comprising such compounds. These compounds are useful in treating, preventing, or slowing the progression of diseases or disorders in a variety of therapeutic areas, such as autoimmune diseases and vascular disease. ##STR00001##