Bristol-Myers Squibb Company
BARCODED PEPTIDE-MHC COMPLEXES AND USES THEREOF

Abstract:

In certain embodiments, the present disclosure provides methods combining (i) screening with DNA-barcoded peptide-major histocompatibility complex (pMHC) to detect T lymphocytes specific for these peptides, and (ii) single-cell sequencing of the T lymphocytes identified in the screening to analyze their transcriptome.