Bristol-Myers Squibb Company
Methods of minimizing glycoprotein agregation in CHO cell production

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Abstract:

In accordance with the present invention, CHO cells expressing a recombinant polypeptide of interest are grown in media where the amino acids, vitamins, phosphate, lipids and/or antioxidant optimization is utilized to manipulate and/or control the protein quality attributes of the polypeptides. Polypeptides expressed in accordance with the present invention may be advantageously used in the preparation of pharmaceutical compositions.

Status:
Grant
Type:

Utility

Filling date:

7 Nov 2016

Issue date:

2 Aug 2022