Bristol-Myers Squibb Company
TRICYCLIC HETEROARYL COMPOUNDS USEFUL AS IRAK4 INHIBITORS

Abstract:

Disclosed are compounds of Formula (I) or a salt or prodrug thereof, wherein: X.sub.1 and X.sub.2 are independently C or N, provided that zero or one of X.sub.1 and X.sub.2 is N; Ring A represented by the structure is: or; and Q, R.sub.1, R.sub.2, R.sub.3, R.sub.4, R.sub.6, and p are define herein. Also disclosed are methods of using such compounds as modulators of IRAK4, and pharmaceutical compositions comprising such compounds. These compounds are useful in treating, preventing, or slowing inflammatory and autoimmune diseases, or in the treatment of cancer. ##STR00001##