Bristol-Myers Squibb Company
Substituted indole compounds useful as inhibitors of TLR7/8/9

Abstract:

Disclosed are compounds of Formula (I) or a salt thereof, wherein: Y is Formula (II), or Formula (III); R.sub.1, R.sub.2, R.sub.2a, R.sub.2b, R.sub.2c, R.sub.3, R.sub.4, R.sub.5, m, and n are defined herein. Also disclosed are methods of using such compounds as inhibitors of signaling through Toll-like receptor 7, or 8, or 9, and pharmaceutical compositions comprising such compounds. These compounds are useful in treating inflammatory and autoimmune diseases. ##STR00001##