| Utility: Substituted tetrahydropyrrolo[1,2-a]pyrazines as alpha v integrin inhibitors Filling date: 6 Sep 2025 Issue date: 5 Apr 2022 | 5 Nov 2018 | 5 Apr 2022 |
| Utility: Alkene spirocyclic compounds as farnesoid X receptor modulators Filling date: 6 Sep 2025 Issue date: 29 Mar 2022 | 31 Oct 2018 | 29 Mar 2022 |
| Utility: Fibronectin binding domains with reduced immunogenicity Filling date: 6 Sep 2025 Issue date: 22 Mar 2022 | 25 Sep 2019 | 22 Mar 2022 |
| Utility: Combination of anti-LAG-3 antibodies and anti-PD-1 antibodies to treat tumors Filling date: 6 Sep 2025 Issue date: 15 Mar 2022 | 11 Sep 2020 | 15 Mar 2022 |
| Utility: Anti-human natural killer cell inhibitory receptor group 2A protein (NKG2A) antibodies Filling date: 6 Sep 2025 Issue date: 15 Mar 2022 | 14 Nov 2019 | 15 Mar 2022 |
| Utility: Methods of treating systemic lupus erythematosus using a domain antibody directed against CD28 Filling date: 6 Sep 2025 Issue date: 8 Mar 2022 | 8 Apr 2020 | 8 Mar 2022 |
| Utility: Cyclohexyl acid triazole azines as LPA antagonists Filling date: 6 Sep 2025 Issue date: 8 Mar 2022 | 18 Dec 2018 | 8 Mar 2022 |
| Utility: Small molecule inhibitors of galectin-3 Filling date: 6 Sep 2025 Issue date: 8 Mar 2022 | 27 Sep 2018 | 8 Mar 2022 |
| Utility: Antagonistic CD40 monoclonal antibodies and uses thereof Filling date: 6 Sep 2025 Issue date: 1 Mar 2022 | 18 Nov 2019 | 1 Mar 2022 |
| Utility: Cyclohexyl acid isoxazole azoles as LPA antagonists Filling date: 6 Sep 2025 Issue date: 1 Mar 2022 | 18 Dec 2018 | 1 Mar 2022 |
| Utility: Pyrazole O-linked carbamoyl cyclohexyl acids as LPA antagonists Filling date: 6 Sep 2025 Issue date: 1 Mar 2022 | 18 Dec 2018 | 1 Mar 2022 |
| Utility: Antagonistic CD40 monoclonal antibodies and uses in treating immune responses Filling date: 6 Sep 2025 Issue date: 22 Feb 2022 | 26 Oct 2020 | 22 Feb 2022 |
| Utility: Substituted bicyclic compounds as farnesoid X receptor modulators Filling date: 6 Sep 2025 Issue date: 22 Feb 2022 | 13 Feb 2020 | 22 Feb 2022 |
| Utility: Inhibitors of indoleamine 2,3-dioxygenase and methods of their use Filling date: 6 Sep 2025 Issue date: 22 Feb 2022 | 29 Aug 2019 | 22 Feb 2022 |
| Utility: Methods of treatment using IL-23p19 monoclonal antibodies Filling date: 6 Sep 2025 Issue date: 22 Feb 2022 | 10 Jun 2019 | 22 Feb 2022 |
| Utility: Process for the preparation of N-((1R,2S,5R)-5-(tert-butylamino)-2-((S)-3-(7-tert-butylpyrazolo[1,5-a][1- ,3,5]triazin-4-ylamino)-2-oxopyrroldin-1-yl)cyclohexyl)acetamide Filling date: 6 Sep 2025 Issue date: 22 Feb 2022 | 19 Jul 2018 | 22 Feb 2022 |
| Utility: Methods of treating diseases associated with fibrosis using modified FGF-21 polypeptides Filling date: 6 Sep 2025 Issue date: 15 Feb 2022 | 28 Jun 2019 | 15 Feb 2022 |
| Utility: Antibodies against MICA and/or MICB and uses thereof Filling date: 6 Sep 2025 Issue date: 8 Feb 2022 | 22 Mar 2019 | 8 Feb 2022 |
| Utility: Amorphous and crystalline forms of IDO inhibitors Filling date: 6 Sep 2025 Issue date: 1 Feb 2022 | 29 Jun 2018 | 1 Feb 2022 |
| Utility: Substituted quinolinylcyclohexylpropanamide compounds and improved methods for their preparation Filling date: 6 Sep 2025 Issue date: 1 Feb 2022 | 29 Jun 2018 | 1 Feb 2022 |
| Utility: Methods and compositions for 18F-radiolabeling of biologics Filling date: 6 Sep 2025 Issue date: 25 Jan 2022 | 24 Nov 2015 | 25 Jan 2022 |
| Utility: Modified relaxin polypeptides comprising a pharmacokinetic enhancer and pharmaceutical compositions thereof Filling date: 6 Sep 2025 Issue date: 18 Jan 2022 | 11 Mar 2021 | 18 Jan 2022 |
| Utility: Treatment of C1013G/CXCR4-associated Waldenstrom's macroglobulinemia with an anti-CXCR4 antibody Filling date: 6 Sep 2025 Issue date: 11 Jan 2022 | 8 Feb 2019 | 11 Jan 2022 |
| Utility: Antagonistic anti-CD40 antibodies and methods of antagonizing CD40 activity Filling date: 6 Sep 2025 Issue date: 11 Jan 2022 | 24 May 2018 | 11 Jan 2022 |
| Utility: Process for preparing indole carboxamide compounds Filling date: 6 Sep 2025 Issue date: 11 Jan 2022 | 31 Aug 2017 | 11 Jan 2022 |
| Utility: Additive systems for use in protein PEGylation Filling date: 6 Sep 2025 Issue date: 4 Jan 2022 | 21 Feb 2020 | 4 Jan 2022 |
| Utility: Antibodies against glucocorticoid-induced tumor necrosis factor receptor (GITR) Filling date: 6 Sep 2025 Issue date: 4 Jan 2022 | 17 Nov 2016 | 4 Jan 2022 |
| Utility: Anti-ICOS agonist antibodies and uses thereof Filling date: 6 Sep 2025 Issue date: 28 Dec 2021 | 13 Mar 2019 | 28 Dec 2021 |
| Utility: Cytokine profiling analysis Filling date: 6 Sep 2025 Issue date: 28 Dec 2021 | 5 Apr 2017 | 28 Dec 2021 |
| Utility: Serum albumin-binding fibronectin type III domains Filling date: 6 Sep 2025 Issue date: 21 Dec 2021 | 23 Aug 2019 | 21 Dec 2021 |
| Utility: Inhibitors of indoleamine 2,3-dioxygenase and methods of their use Filling date: 6 Sep 2025 Issue date: 21 Dec 2021 | 8 Oct 2018 | 21 Dec 2021 |
| Utility: Diazaspiro ROCK inhibitors Filling date: 6 Sep 2025 Issue date: 7 Dec 2021 | 1 Nov 2018 | 7 Dec 2021 |
| Utility: Method of treating cardiovascular disease and heart failure with modified relaxin polypeptides Filling date: 6 Sep 2025 Issue date: 30 Nov 2021 | 27 Feb 2019 | 30 Nov 2021 |
| Utility: Piperidinone formyl peptide 2 receptor and formyl peptide 1 receptor agonists Filling date: 6 Sep 2025 Issue date: 30 Nov 2021 | 8 Jun 2018 | 30 Nov 2021 |
| Utility: Isoxazole o-linked carbamoyl cyclohexyl acids as LPA antagonists Filling date: 6 Sep 2025 Issue date: 23 Nov 2021 | 18 Dec 2018 | 23 Nov 2021 |
| Utility: Antibody polypeptides that antagonize CD40L Filling date: 6 Sep 2025 Issue date: 23 Nov 2021 | 12 Dec 2018 | 23 Nov 2021 |
| Utility: Cyclopropyl urea formyl peptide 2 receptor and formyl peptide 1 receptor agonists Filling date: 6 Sep 2025 Issue date: 23 Nov 2021 | 8 Jun 2018 | 23 Nov 2021 |
| Utility: Dimethoxyphenyl substituted indole compounds as TLR7, TLR8 or TLR9 inhibitors Filling date: 6 Sep 2025 Issue date: 23 Nov 2021 | 27 Jul 2017 | 23 Nov 2021 |
| Utility: PD-L1 binding polypeptides for imaging Filling date: 6 Sep 2025 Issue date: 16 Nov 2021 | 24 Jul 2019 | 16 Nov 2021 |
| Utility: Isofuranone compounds useful as HPK1 inhibitors Filling date: 6 Sep 2025 Issue date: 9 Nov 2021 | 5 Nov 2018 | 9 Nov 2021 |
| Utility: Fibronectin based scaffold proteins having improved stability Filling date: 6 Sep 2025 Issue date: 2 Nov 2021 | 11 Mar 2019 | 2 Nov 2021 |
| Utility: Benzofuran derivatives for the treatment of hepatitis C Filling date: 6 Sep 2025 Issue date: 2 Nov 2021 | 17 Mar 2017 | 2 Nov 2021 |
| Utility: Anti-TREM-1 antibodies and uses thereof Filling date: 6 Sep 2025 Issue date: 26 Oct 2021 | 1 Apr 2019 | 26 Oct 2021 |
| Utility: Targeted therapeutics based on engineered proteins for tyrosine kinases receptors, including IGF-IR Filling date: 6 Sep 2025 Issue date: 19 Oct 2021 | 10 Jan 2019 | 19 Oct 2021 |
| Utility: Antibodies to alpha-synuclein and uses thereof Filling date: 6 Sep 2025 Issue date: 12 Oct 2021 | 16 Feb 2018 | 12 Oct 2021 |
| Utility: Methods of treating immune diseases by administering antibody polypeptides that antagonize CD40 Filling date: 6 Sep 2025 Issue date: 5 Oct 2021 | 20 Dec 2019 | 5 Oct 2021 |
| Utility: Macrocycles as factor XIA inhibitors Filling date: 6 Sep 2025 Issue date: 5 Oct 2021 | 21 Nov 2019 | 5 Oct 2021 |
| Utility: [1,2,4]Triazolo[4,3-A]pyridinyl substituted indole compounds Filling date: 6 Sep 2025 Issue date: 28 Sep 2021 | 3 Aug 2018 | 28 Sep 2021 |
| Utility: Aryl heterocyclic piperidinone formyl peptide 2 receptor and formyl peptide 1 receptor agonists Filling date: 6 Sep 2025 Issue date: 21 Sep 2021 | 8 Jun 2018 | 21 Sep 2021 |
| Utility: Phenylpyrrolidinone formyl peptide 2 receptor agonists Filling date: 6 Sep 2025 Issue date: 14 Sep 2021 | 24 Apr 2020 | 14 Sep 2021 |
