BioNTech SE
Peptide mimotopes of the CD3 T-cell co-receptor epsilon chain and uses thereof

Abstract:

The present invention provides molecules that mimic antigenic determinants of the CD3 (cluster of differentiation 3) T-cell co-receptor epsilon chain (CD3.epsilon.). These molecules compete with CD3.epsilon. for binding to a CD3.epsilon. binding domain. e.g. a CD3.epsilon. binding domain of an antibody, and are capable of detecting antibodies against CD3.epsilon.. The mimotopes of the invention may be used to generate or inhibit immune responses in animals and preferably humans. Additionally, they may serve as tools for anti-CD3.epsilon. antibody purification and the detection of anti-CD3.epsilon. antibodies in biological samples.