C4 Therapeutics, Inc.
C3-carbon linked glutarimide degronimers for target protein degradation

Abstract:

This invention provides Degronimers that have carbon-linked E3 Ubiquitin Ligase targeting moieties (Degrons), which can be linked to a targeting ligand for a protein that has been selected for in vivo degradation, and methods of use and compositions thereof as well as methods for their preparation.