ChemoCentryx, Inc.
Triaryl compounds for treatment of PD-L1 diseases

Abstract:

Compounds are provided that are useful as immunomodulators. The compounds have the Formula (I) ##STR00001## including stereoisomers and pharmaceutically acceptable salts thereof, wherein R.sup.1a, R.sup.1b, R.sup.1c, R.sup.1d, R.sup.2a, R.sup.2b, R.sup.3, R.sup.3a, R.sup.4, R.sup.6, R.sup.7, R.sup.8, A, Z, X.sup.1 and n are as defined herein. Methods associated with preparation and use of such compounds, as well as pharmaceutical compositions comprising such compounds, are also disclosed.