Cidara Therapeutics, Inc.
VARIANT FC DOMAINS AND USES THEREOF

Abstract:

This disclosure relates to variant Fc domain monomers, fusion proteins, conjugates, compositions, and related methods for treating or preventing disease. In particular, the invention features variant Fc domain monomers which include mutations at position 220, and 252, 254, and/or 256 or 309, 311, and/or 434 according to the Kabat Index numbering. The invention also features variant Fc domain monomers including mutations at position 220 according to the Kabat index number, wherein the variant Fc domain monomer is between 200 and 300 amino acid residues in length and/or is between about 20 kDa and about 40 kDa in mass.