Canopy Growth Corporation
METHODS FOR PREPARING CANNABINOIDS BY BASE-PROMOTED DOUBLE-BOND MIGRATION

Abstract:

Disclosed is a method for converting a first cannabinoid into a second cannabinoid that is a regioisomer of the first cannabinoid. The method comprising contacting the first cannabinoid with: (i) a base having a pKb that is less than a critical pKb for the first cannabinoid; and (ii) a solvent system comprising a polar solvent such as dimethyl sulfoxide (DMSO), triethylamine (TEA), or a combination thereof.