Curis, Inc.
Phosphoinositide 3-kinase inhibitor with a zinc binding moiety

Abstract:

The invention provides a compound of Formula I, ##STR00001## Pharmaceutical compositions comprising such compounds and the use of such compounds in the treatment of phosphoinositide 3-kinase related diseases and disorders such as cancer. The instant application further relates to the treatment of histone deacetylase related disorders and diseases related to both histone deacetylase and phosphoinositide 3-kinase.