CRISPR Therapeutics AG
COMPOSITIONS AND METHODS FOR DIFFERENTIATING STEM CELLS INTO NK CELLS

Abstract:

The disclosure features methods and compositions for differentiating stem cells into hematopoietic stem and progenitor cells (HSPC) and/or Natural Killer (NK) cells. The methods and compositions described herein are used to differentiate stem or progenitor cells having at least one gene-edit that is maintained in the differentiated cell. Also provided are differentiated cells produced using the methods and compositions described herein for therapeutic applications.