Cortexyme, Inc.
Aminopyridine compounds and methods for the preparation and use thereof
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Abstract:
The present invention relates generally to therapeutics targeting the bacterium Porphyromonas gingivalis, including its proteases arginine gingipain A/B (Rgp), and their use for the treatment of disorders associated with P. gingivalis infection, including brain disorders such as Alzheimer's disease. In certain embodiments, the invention provides compounds according to Formula I and Formula III, as described herein, and pharmaceutically acceptable salts thereof.
Status:
Grant
Type:
Utility
Filling date:
8 Nov 2019
Issue date:
13 Jul 2021