Cortexyme, Inc.
Aminopyridine compounds and methods for the preparation and use thereof

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Abstract:

The present invention relates generally to therapeutics targeting the bacterium Porphyromonas gingivalis, including its proteases arginine gingipain A/B (Rgp), and their use for the treatment of disorders associated with P. gingivalis infection, including brain disorders such as Alzheimer's disease. In certain embodiments, the invention provides compounds according to Formula I and Formula III, as described herein, and pharmaceutically acceptable salts thereof.

Status:
Grant
Type:

Utility

Filling date:

8 Nov 2019

Issue date:

13 Jul 2021