Cortexyme, Inc.
Ketone inhibitors of lysine gingipain
Last updated:
Abstract:
The present invention provides compounds according to Formula I as described herein, and their use for inhibiting the lysine gingipain protease (Kgp) from the bacterium Porphyromonas gingivalis. Also described are gingipain activity probe compounds and methods for assaying gingipain activity are also described, as well as methods for the treatment of disorders associated with P. gingivalis infection, including brain disorders such as Alzheimer's disease.
Status:
Grant
Type:
Utility
Filling date:
14 Mar 2019
Issue date:
4 Aug 2020