Cortexyme, Inc.
Inhibitors of lysine gingipain

Last updated:

Abstract:

The present invention relates generally to therapeutics targeting the bacterium Porphyromonas gingivalis, including its protease Lysine gingipain (Kgp), and their use for the treatment of disorders associated with P. gingivalis infection, including brain disorders such as Alzheimer's disease. In certain embodiments, the invention provides compounds according to Formula I, as described herein, and pharmaceutically acceptable salts thereof. ##STR00001##

Status:
Grant
Type:

Utility

Filling date:

4 May 2020

Issue date:

17 May 2022