Cue Biopharma, Inc.
T-CELL MODULATORY POLYPEPTIDES AND METHODS OF USE THEREOF
Last updated:
Abstract:
The present disclosure provides T-cell modulatory polypeptides (TMPs) that comprise an immunomodulatory polypeptide, class I HLA polypeptides (a class I HLA heavy chain polypeptide and a .beta.2 microglobulin polypeptide), and a KRAS peptide (e.g., a KRAS peptide comprising a cancer-associated mutation) that presents an epitope to a T-cell receptor. A TMP is useful for modulating the activity of a T cell, and for modulating an immune response in an individual.
Status:
Application
Type:
Utility
Filling date:
25 Jan 2022
Issue date:
12 May 2022