Cue Biopharma, Inc.
T-CELL MODULATORY POLYPEPTIDES AND METHODS OF USE THEREOF

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Abstract:

The present disclosure provides T-cell modulatory polypeptides (TMPs) that comprise an immunomodulatory polypeptide, class I HLA polypeptides (a class I HLA heavy chain polypeptide and a .beta.2 microglobulin polypeptide), and a KRAS peptide (e.g., a KRAS peptide comprising a cancer-associated mutation) that presents an epitope to a T-cell receptor. A TMP is useful for modulating the activity of a T cell, and for modulating an immune response in an individual.

Status:
Application
Type:

Utility

Filling date:

25 Jan 2022

Issue date:

12 May 2022