Denali Therapeutics Inc.
PHOSPHO-RAB ANTIBODIES, ASSAYS AND METHODS OF USE THEREOF

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Abstract:

In one aspect, antibodies that specifically bind to a phosphorylated Rab protein are provided. In some embodiments, the antibody is a monoclonal antibody that specifically binds to a phosphorylated human Rab10 protein and recognizes an epitope within or comprising the sequence AGQERFH(pT)ITTSYYR. In some embodiments, the antibody is a monoclonal antibody that specifically binds to a phosphorylated human Rab8a protein and recognizes an epitope within or comprising the sequence QERFR(pT)ITTAY. Methods and materials for detecting LRRK2 and Rab protein are also provided.

Status:
Application
Type:

Utility

Filling date:

15 Jun 2018

Issue date:

20 May 2021