Denali Therapeutics Inc.
TRANSFERRIN RECEPTOR-BINDING POLYPEPTIDES AND USES THEREOF

Abstract:

The present disclosure relates generally to Fc polypeptide dimers that contain a non-native transferrin receptor (TfR) binding site, do not substantially deplete reticulocytes in vivo, but retain binding to the Fc.gamma. receptor (Fc.gamma.R). The present disclosure also relates to an Fc polypeptide dimer that contains a non-native site that specifically binds TfR on one of the Fc polypeptides; a modification or modifications on the Fc polypeptide containing the TfR-binding site that reduces Fc.gamma.R binding when bound to TfR, where the other Fc polypeptide does not contain a TfR-binding site but retains Fc.gamma.R binding.