Enanta Pharmaceuticals, Inc.
Bile acid derivatives as FXR/TGR5 agonists and methods of use thereof

Abstract:

The present invention provides compounds represented by Formula I, or pharmaceutically acceptable salts, stereoisomers, solvates, hydrates or combination thereof, ##STR00001## The invention also provides pharmaceutical compositions comprising these compounds and methods of using this compounds for treating FXR-mediated or TGR5-mediated diseases or conditions.