Enanta Pharmaceuticals, Inc.
Bile acid analogs as FXR/TGR5 agonists and methods of use thereof

Abstract:

The present invention relates to compounds of Formula (IA) and Formula (IB), ##STR00001## and pharmaceutically acceptable salts thereof, where R.sub.1, R.sub.2, R.sub.3, R.sub.4, R.sub.5, R.sub.6, R.sub.7, R.sub.8, R.sub.9 and m are as defined herein, pharmaceutical compositions comprising these compounds and methods of use of these compounds for treating a TGR5 mediated disease or condition.