EyeGate Pharmaceuticals, Inc.
COMPOSITIONS AND METHODS FOR TREATING OCULAR DISEASE BY CONTACT LENS MEDIATED DRUG DELIVERY

Abstract:

The disclosure provides an ocular drug delivery system that includes a contact lens and a drug delivery portion, which may include a compound having the formula X--(CH2)n-Z, wherein X is a photocrosslinkable group. Advantageously, the drug delivery portion may aid in loading a high concentration of a negatively-charged therapeutic agent into the ocular drug delivery system. Additionally, the disclosed ocular drug delivery system may aid in controlled delivery of the negatively-charged therapeutic agent to the eye of a patient over a period of about 4 to about 24 hours.