Gilead Sciences, Inc.
Substituted 3,4,5,6,8,10,14,14a-octahydro-2h-2,6-methanopyrido[1',2':4,5]pyrazino[2,1- -b][1,3]oxazocines and methods for treating viral infections

Abstract:

Compounds for use in the treatment of human immunodeficiency virus (HIV) infection are disclosed. The compounds have the following Formula (I): ##STR00001## including stereoisomers and pharmaceutically acceptable salts thereof, wherein R.sup.1, X, W, Y.sup.1, Y.sup.2, Z.sup.1, and Z.sup.4 are as defined herein. Methods associated with preparation and use of such compounds, as well as pharmaceutical compositions comprising such compounds, are also disclosed.