Gilead Sciences, Inc.
INTERLEUKIN-2-Fc FUSION PROTEINS AND METHODS OF USE

Abstract:

Provided are serum half-life extended-IL-2 variant (IL-2v) heterodimers having reduced binding to the IL2R.alpha. (CD25) subunit. In particular, Fc-IL-2v heterodimers are provided and methods for making and using, e.g. for enhancing an immune response, e.g. in the prevention and treatment of viral infections and cancer.