Corning Incorporated
FLOW CELLS WITH STABLE POLYMER COATING AND THEIR USES FOR GENE SEQUENCING

Abstract:

A flow cell article is provided where the flow cell article includes a substrate having one or more layers; a fluidic channel disposed in the substrate wherein the fluidic channel includes at least one reactive surface comprising: a coupling agent having a first functional group covalently attached to the substrate of the fluidic channel and a second imide functional group covalently attached to a polymer of formula (I), where R.sub.1 is a residue of an unsaturated monomer that has been copolymerized with maleic anhydride; R.sub.2 is H, an alkyl group, an oligo(ethylene glycol), and/or a dialkyl amine; m, n, and o are each from 1 to 10,000; X is a divalent NH, O, and/or S; and Z is the first functional group.