Genmab A/S
Methods of inducing T cell activation by administering an antibody comprising CD40 and 4-1BB (CD137) binding domains

Abstract:

The present invention relates to binding agents binding to receptors of the TNF superfamily, in particular binding agents binding to at least two different receptors of the TNF superfamily, as well as to their use in medicine. The present invention further relates to nucleic acid molecules encoding such binding agents, to cells comprising such nucleic acid molecules and to pharmaceutical compositions and kits.