Genmab A/S
ANTIBODY VARIANTS HAVING MODIFICATIONS IN THE CONSTANT REGION

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Abstract:

The present invention relates to positions in the constant region of antibodies, in particular the CH3 region of IgG4, which affect the strength of CH3-CH3 interactions. Mutations that either stabilize or destabilize this interaction are disclosed.

Status:
Application
Type:

Utility

Filling date:

16 Nov 2020

Issue date:

27 May 2021