Genmab A/S
ANTIBODY VARIANTS HAVING MODIFICATIONS IN THE CONSTANT REGION
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Abstract:
The present invention relates to positions in the constant region of antibodies, in particular the CH3 region of IgG4, which affect the strength of CH3-CH3 interactions. Mutations that either stabilize or destabilize this interaction are disclosed.
Status:
Application
Type:
Utility
Filling date:
16 Nov 2020
Issue date:
27 May 2021