Genmab A/S
STABLE IgG4 ANTIBODIES

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Abstract:

The present invention relates to novel stabilized IgG4 antibodies, to methods of producing such antibodies and to uses of such antibodies as a medicament. In a main aspect, the invention relates to a stabilized IgG4 antibody, comprising a heavy chain and a light chain, wherein said heavy chain comprises a human IgG4 constant region having a substitution of the Arg residue at position (409), the Phe residue at position (405) or the Lys residue at position (370).

Status:
Application
Type:

Utility

Filling date:

15 Jul 2020

Issue date:

4 Mar 2021