Genmab A/S
MULTISPECIFIC ANTIGEN-BINDING MOLECULE WITH IMPROVED INTERNALIZATION CHARACTERISTICS

Abstract:

The present invention relates to a multispecific antigen-binding molecule comprising a first antigen-binding domain and a second antigen-binding domain. The first domain specifically binds a target molecule (T), and the second domain specifically binds an internalizing effector protein (E), the second antigen-binding domain having a dissociation constant (K.sub.D) with E of between 10.sup.-9 and 10.sup.-8 M. The multispecific antigen-binding molecule is useful in a method for treating and/or preventing a cancer.