Gamida Cell Ltd.
METHOD OF HOMING AND RETENTION OF GAMMADELTA T CELLS, OPTIONALLY WITH NATURAL KILLER CELLS, FOR GENERATING CELL COMPOSITIONS FOR USE IN THERAPY

Abstract:

Methods of ex-vivo culture of gammadelta T-cells and gammadelta T-cell enriched cell populations are provided and, more particularly, methods for enhancing functionality of gammadelta T-cell populations by treating the cells with a nicotinamide in combination with cytokines enhancing gammadelta T-cell homing and/or retention potential. Also envisioned are compositions comprising cultured gammadelta T-cells and mixed gammadelta T-cell enriched cell populations and therapeutic uses thereof.