Heat Biologics, Inc.
Compositions and methods for adjoining type I and type II extracellular domains as heterologous chimeric proteins

Abstract:

The present invention relates to, inter alia, compositions and methods, including chimeric proteins that find use in the treatment of disease, such as immunotherapies for cancer and autoimmunity. In part, the invention provides, in various embodiments, fusions of extracellular domains of transmembrane proteins that can have stimulatory or inhibitory effects.